Bulk quantities of Ovine IL-6 protein are available.
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Molecular Weight (calculated) - 20.4kDa
Amino Acid Sequence - GPLGEDFKND TTPSRLLLTT PEKTEALIKH IVDKISAIRK EICEKNDECE NSKETLAENK LKLPKMEEKD GCFQSGFNQA ICLIKTTAGL LEYQIYLDFL QNEFEGNQET VMELQSSIRT LIQILKEKIA GLITTPATHT DMLEKMQSSN EWVKNAKVII ILRSLENFLQ FSLRAIRMK (179)
Gene ID - 443406
Homology Across Species
Ovis aries (sheep) IL-6 – 100%
Capra hircus (goat) IL-6 – 99%
Pantholops hodgsonii (chiru) IL-6 – 96%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.
Alternate Names - IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
Development and validation of ELISAs for the quantitation of interleukin (IL)-1β, IL-6, IL-8 and IL-10 in ovine plasma.
Bouquet M, Passmore MR, See Hoe LE, Tung JP, Simonova G, Boon AC, Fraser JF.
J Immunol Methods. 2020 Aug 20:112835. doi: 10.1016/j.jim.2020.112835. Online ahead of print.
Applications: Standards for the measurement of ovine IL-1 beta, IL-6, IL-8, and IL-10 in plasma by ELISA
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